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中心特設此欄目以方便大家尋索本港的愛滋病病毒/愛滋病研究刊物和研究結果。如 閣下發表了有關愛滋病病毒/愛滋病的期刊文章或摘要，並希望將它們放置於此欄目內，請以電郵與我們聯絡 rrc@dh.gov.hk。

2019

  1. Xu XY, Wang DY, Ku CF, Zhao Y, Cheng H, Liu KL, Rong LJ, Zhang HJ. Anti-HIV lignans from Justicia procumbens. Chin J Nat Med. 2019 Dec;17(12):945-952. doi: 10.1016/S1875-5364(19)30117-7.
  2. Ryang J, Yan Y, Song Y, Liu F, Ng TB. Anti-HIV, antitumor and immunomodulatory activities of paclitaxel from fermentation broth using molecular imprinting technique. AMB Express. 2019 Dec 3;9(1):194. doi: 10.1186/s13568-019-0915-1.
  3. Cheung AKL, Huang Y, Chen M, Chen ZW. Transfer of HIV-1 from HIV-1 latently infected CD34+ haematopoietic progenitors to CD4+ T cells. Hong Kong Med J. 2019 Oct;25 Suppl 7(5):37-40.
  4. Zhuang K, Zhang Y, Zhou L, Qi X, Xu X, Meng F, Xu Z, Liu J, Shao L, Liu H, Liu H, Fang J, Deng D, Peng J, Zhou F, Liu L, Tang H, Xiong Y, Ho W, Guo D, Ke H, Gui X. Isolation and characterization of spontaneously immortalized B-lymphocyte lines from HIV-infected patients with and without non-Hodgkin's Lymphoma. Cancer Med. 2019 Nov;8(15):6741-6755. doi: 10.1002/cam4.2508. Epub 2019 Sep 20.
  5. Ahmed SF, Quadeer AA, Morales-Jimenez D, McKay MR. Sub-dominant principal components inform new vaccine targets for HIV Gag. Bioinformatics. 2019 Oct 15;35(20):3884-3889. doi: 10.1093/bioinformatics/btz524.
  6. Ling L, Wu T, To KKW, Cheung KW, Lui KOL, Niu M, Lam KS, Wang CC, Li J, Wang H, Yuen KY, Chen Z. Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice. AIDS. 2019 Mar 15;33(4):F1-F12. doi: 10.1097/QAD.0000000000002149.
  7. Cui H, Geng W, Sun H, Han X, An M, Jiang Y, Zhang Z, Chen Z, Xu J, Hu Q, Zhao B, Zhou B, Shang H. Rapid CD4+ T-cell decline is associated with coreceptor switch among MSM primarily infected with HIV-1 CRF01_AE in Northeast China. AIDS. 2019 Jan 27;33(1):13-22. doi: 10.1097/QAD.0000000000001981.

2018

  1. Chen Z. Monkey Models and HIV Vaccine Research. Adv Exp Med Biol. 2018;1075:97-124. doi: 10.1007/978-981-13-0484-2_5. (Search PubMed)
  2. Cheung KW, Wu T, Ho SF, Wong YC, Liu L, Wang H, Chen Z. α4β7+ CD4+ Effector/Effector Memory T Cells Differentiate into Productively and Latently Infected Central Memory T Cells by Transforming Growth Factor β1 during HIV-1 Infection. J Virol. 2018 Mar 28;92(8). pii: e01510-17. doi: 10.1128/JVI.01510-17. Print 2018 Apr 15. (Search PubMed)
  3. Li J, Wang W, Tong P, Leung CK, Yang G, Li Z, Li N, Sun X, Han Y, Lu C, Kuang D, Dai J, Zeng X. Autophagy Induction by HIV-Tat and Methamphetamine in Primary Midbrain Neuronal Cells of Tree Shrews via the mTOR Signaling and ATG5/ATG7 Pathway. Front Neurosci. 2018 Dec 6;12:921. doi: 10.3389/fnins.2018.00921. eCollection 2018. (Search PubMed)
  4. Liu W, Wong YC, Chen SMY, Tang J, Wang H, Cheung AKL, Chen Z. DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses. Vaccine. 2018 Jul 25;36(31):4621-4632. doi: 10.1016/j.vaccine.2018.06.047. Epub 2018 Jun 28. (Search PubMed)
  5. Louie RHY, Kaczorowski KJ, Barton JP, Chakraborty AK, McKay MR. Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E564-E573. doi: 10.1073/pnas.1717765115. Epub 2018 Jan 8.
  6. Pasayan MKU, Mationg MLS, Boettiger D, Lam W, Zhang F, Wen-Wei Ku S, Merati TP, Chaiwarith R, Cuong DD, Yunihastuti E, Kiertiburanakul S, Van Kinh N, Avihingsanon A, Sun LP, Kamarulzaman A, Kantipong P, Kumarasamy N, Pujari S, Heng Sim BL, Ng OT, Choi JY, Tanuma J, Ross J, Ditangco R. Effect of Macrolide Prophylactic Therapy on AIDS-Defining Conditions and HIV-Associated Mortality. J Acquir Immune Defic Syndr. 2018 Dec 10. doi: 10.1097/QAI.0000000000001933. [Epub ahead of print] (Search PubMed)
  7. Quadeer AA, Morales-Jimenez D, McKay MR. Co-evolution networks of HIV/HCV are modular with direct association to structure and function. PLoS Comput Biol. 2018 Sep 7;14(9):e1006409. doi: 10.1371/journal.pcbi.1006409. eCollection 2018 Sep. (Search PubMed)
  8. Sun Z, Yan L, Tang J, Qian Q, Lenberg J, Zhu D, Liu W, Wu K, Wang Y, Lu S. Brief introduction of current technologies in isolation of broadly neutralizing HIV-1 antibodies. Virus Res. 2018 Jan 2;243:75-82. doi: 10.1016/j.virusres.2017.10.011. Epub 2017 Oct 16. Review. (Search PubMed)
  9. Tsang HF, Chan LW, Tong JC, Wong HT, Lai CK, Au TC, Chan AK, Ng LP, Cho WC, Wong SC. Implementation and new insights in molecular diagnostics for HIV infection. Expert Rev Mol Diagn. 2018 May;18(5):433-441. doi: 10.1080/14737159.2018.1464393. Epub 2018 Apr 19. (Search PubMed)
  10. Wang Q, Wong CH, Chan HYE, Lee WY, Zuo Z. Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery. Int J Pharm. 2018 Mar 25;539(1-2):50-57. doi: 10.1016/j.ijpharm.2018.01.032. Epub 2018 Jan 31. (Search PubMed)
  11. Wu X, Guo J, Niu M, An M, Liu L, Wang H, Jin X, Zhang Q, Lam KS, Wu T, Wang H, Wang Q, Du Y, Li J, Cheng L, Tang HY, Shang H, Zhang L, Zhou P, Chen Z. Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. J Clin Invest. 2018 Jun 1;128(6):2239-2251. doi: 10.1172/JCI96764. Epub 2018 Apr 23.
  12. Yang Z, Liu X, Sun Z, Li J, Tan W, Yu W, Zhang M. Identification of a HIV Gp41-Specific Human Monoclonal Antibody With Potent Antibody-Dependent Cellular Cytotoxicity. Front Immunol. 2018 Nov 16;9:2613. doi: 10.3389/fimmu.2018.02613. eCollection 2018. (Search PubMed)
  13. Yew WW, Chan DP, Singhal A, Zhang Y, Lee SS. Does oxidative stress contribute to adverse outcomes in HIV-associated TB? J Antimicrob Chemother. 2018 May 1;73(5):1117-1120. doi: 10.1093/jac/dkx509. (Search PubMed)
  14. Zeng XF, Li Q, Li J, Wong N, Li Z, Huang J, Yang G, Sham PC, Li SB, Lu G. HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling. Toxicol Lett. 2018 Dec 15;299:159-171. doi: 10.1016/j.toxlet.2018.09.009. Epub 2018 Sep 24. (Search PubMed)
  15. Zhao Y, Lin L, Xiao Z, Li M, Wu X, Li W, Li X, Zhao Q, Wu Y, Zhang H, Yin J, Zhang L, Cho CH, Shen J. Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application. J Immunol Res. 2018 Jul 10;2018:5081634. doi: 10.1155/2018/5081634. eCollection 2018. Review. (Search PubMed)

2017

  1. Cheung AKL, Kwok HY, Huang Y, Chen M, Mo Y, Wu X, Lam KS, Kong HK, Lau TCK, Zhou J, Li J, Cheng L, Kiat Lee B, Peng Q, Lu X, An M, Wang H, Shang H, Zhou B, Wu H, Xu A, Yuen KY, Chen Z. Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection. Nat Microbiol. 2017 Oct;2(10):1389-1402. doi: 10.1038/s41564-017-0006-5. Epub 2017 Aug 14. (Search PubMed)

  2. Sun Z, Lu S, Yang Z, Li J, Zhang MY. Construction of a recombinant full-length membrane associated IgG library. Virus Res. 2017 Jun 15;238:156-163. doi: 10.1016/j.virusres.2017.06.018. Epub 2017 Jun 24. (Search PubMed)

  3. Cheung AKL, Huang Y, Kwok HY, Chen M, Chen Z. Latent human cytomegalovirus enhances HIV-1 infection in CD34+ progenitor cells. Blood Adv. 2017 Jan 16;1(5):306-318. doi: 10.1182/bloodadvances.2016000638. eCollection 2017 Jan 24. (Search PubMed)

  4. Tang X, Guo J, Cheng L, Sun C, Liu L, Zuo T, Wang H, Chen L, Zhang L, Chen Z. Single N277A substitution in C2 of simian immunodeficiency virus envelope influences vaccine-elicited CD4i neutralizing and anti-V2 antibody responses. Vaccine. 2017 May 2;35(19):2582-2591. doi: 10.1016/j.vaccine.2017.03.062. Epub 2017 Mar 31. (Search PubMed)

  5. Zhang HJ, Rumschlag-Booms E, Guan YF, Wang DY, Liu KL, Li WF, Nguyen VH, Cuong NM, Soejarto DD, Fong HHS, Rong L. Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa. J Nat Prod. 2017 Jun 23;80(6):1798-1807. doi: 10.1021/acs.jnatprod.7b00004. Epub 2017 Jun 14. (Search PubMed)

  6. Wang Y, Lin HQ, Wang P, Hu JS1, Ip TM, Yang LM, Zheng YT, Chi-Cheong Wan D. Discovery of a Novel HIV-1 Integrase/p75 Interacting Inhibitor by Docking Screening, Biochemical Assay, and in Vitro Studies. J Chem Inf Model. 2017 Sep 25;57(9):2336-2343. doi: 10.1021/acs.jcim.7b00402. Epub 2017 Sep 11. (Search PubMed)

  7. Wang Q, Zhang Y, Wong CH, Edwin Chan HY, Zuo Z. Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling. AAPS J. 2017 Dec 27;20(1):23. doi: 10.1208/s12248-017-0179-0. (Search PubMed)

  8. Jou E, Gligich O, Chan AC, Mohan D, Felsen UR, Ayyappan S, Billett HH, Hui EP, Chan AT, Raghupathy R. Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients. Hematol Oncol. 2017 Mar;35(1):64-68. doi: 10.1002/hon.2247. Epub 2015 Jul 24. (Search PubMed)

  9. Liu F, Wang Y, Zhang K, Wang Y, Zhou R, Zeng Y, Han Y, Ng TB. A novel polysaccharide with antioxidant, HIV protease inhibiting and HIV integrase inhibiting activities from Fomitiporia punctata (P. karst.) murrill (Basidiomycota, hymenochaetales). Int J Biol Macromol. 2017 Apr;97:339-347. doi: 10.1016/j.ijbiomac.2017.01.030. Epub 2017 Jan 12. (Search PubMed)

  10. Sun Z, Lu S, Yang Z, Li J, Zhang M. Isolation and characterization of an HIV-1 envelope glycoprotein-specific B-cell from an immortalized human naïve B-cell library. J Gen Virol. 2017 Apr;98(4):791-798. doi: 10.1099/jgv.0.000706. Epub 2017 Apr 13. (Search PubMed)

  11. Zhang HJ, Rumschlag-Booms E, Guan YF, Liu KL, Wang DY, Li WF, Nguyen VH, Cuong NM, Soejarto DD, Fong HHS, Rong L. Anti-HIV diphyllin glycosides from Justicia gendarussa. Phytochemistry. 2017 Apr;136:94-100. doi: 10.1016/j.phytochem.2017.01.005. Epub 2017 Jan 19. (Search PubMed)

2016

  1. Cheung KW, Peng Q, He L, Cai K, Jiang Q, Zhou B, To SW, Yam WC, Liu L, Chen Z, Wang H. Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System. PLoS One. 2016 Apr 19;11(4):e0153641. doi: 10.1371/journal.pone.0153641. eCollection 2016. (Search PubMed)

  2. Wang Q, Zhang Y, Qian S, Peng S, Zhang Q, Wong CH, Chan HY, Zuo Z. Pharmacokinetics and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Jun 5;125:41-7. doi: 10.1016/j.jpba.2016.03.025. Epub 2016 Mar 14. (Search PubMed)

  3. Zhang XM, Zhang Q, Wu H, Lau TC, Liu X, Chu H, Zhang K, Zhou J, Chen ZW, Jin DY, Zheng BJ. Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern. AIDS Res Hum Retroviruses. 2016 Sep;32(9):909-17. doi: 10.1089/AID.2015.0359. Epub 2016 May 9. (Search PubMed)

  4. Au KY, Shi WW, Qian S, Zuo Z, Shaw PC. Improvement of the Pharmacological Properties of Maize RIP by Cysteine-Specific PEGylation. Toxins (Basel). 2016 Oct 17;8(10). pii: E298. (Search PubMed)

  5. Liu L, Wang W, Matz J, Ye C, Bracq L, Delon J, Kimata JT, Chen Z, Benichou S, Zhou P. The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1. J Virol. 2016 Nov 14;90(23):10642-10659. Print 2016 Dec 1. (Search PubMed)

  6. Guan Y, Wang D, Tan GT, Van Hung N, Cuong NM, Pezzuto JM, Fong HH, Soejarto DD, Zhang H. Litsea Species as Potential Antiviral Plant Sources. Am J Chin Med. 2016;44(2):275-90. doi: 10.1142/S0192415X16500166. (Search PubMed)

2014

  1. Wu H, Zhang X, Zhang H, Zhang Q, Chen Z, Huang J, Lee S, Zheng B. In Vitro Selection of HIV-1 CRF08_BC Variants Resistant to Reverse Transcriptase Inhibitors. AIDS Res Hum Retroviruses. 2014 Dec 6. [Epub ahead of print] (Search PubMed)

  2. Wong JH, Liu Z, Law KW, Liu F, Xia L, Wan DC, Ng TB. A study of effects of peptide fragments of bovine and human lactoferrins on activities of three key HIV-1 enzymes. Peptides. 2014 Nov 1;62C:183-188. doi: 10.1016/j.peptides.2014.07.006. [Epub ahead of print] (Search PubMed)

  3. Gu WG, Zhang X, Ip DT, Yang LM, Zheng YT, Wan DC. Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging. FEBS Lett. 2014 Sep 17;588(18):3461-8. doi: 10.1016/j.febslet.2014.08.004. Epub 2014 Aug 13. (Search PubMed)

  4. Gu WG, Ip DT, Liu SJ, Chan JH, Wang Y, Zhang X, Zheng YT, Wan DC.1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor. Chem Biol Interact. 2014 Apr 25;213:21-7. doi: 10.1016/j.cbi.2014.01.011. Epub 2014 Jan 28. (Search PubMed)

  5. Zhang L, Zhu C, Guo Y, Wei F, Lu J, Qin J, Banerjee S, Wang J, Shang H, Verma SC, Yuan Z, Robertson ES, Cai Q. Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jκ. J Virol. 2014 Jun;88(12):6873-84. doi: 10.1128/JVI.00283-14. Epub 2014 Apr 2. (Search PMC)

  6. Pan W, Liu K, Guan Y, Tan GT, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH, Zhang H. Bioactive compounds from Vitex leptobotrys. J Nat Prod. 2014 Mar 28;77(3):663-7. doi: 10.1021/np400779v. Epub 2014 Jan 9. (Search PubMed)

  7. Au KY, Wang RR, Wong YT, Wong KB, Zheng YT, Shaw PC. Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells. Biochim Biophys Acta. 2014 Mar;1840(3):958-63. doi: 10.1016/j.bbagen.2013.11.005. Epub 2013 Nov 15. (Search PubMed)

  8. Zhang X, Huang SZ, Gu WG, Yang LM, Chen H, Zheng CB, Zhao YX, Wan DC, Zheng YT. Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation. Chin J Nat Med. 2014 Mar;12(3):186-93. doi: 10.1016/S1875-5364(14)60031-5. (Search PubMed)

  9. Wang CR, Zhou R, Ng TB, Wong JH, Qiao WT, Liu F. First report on isolation of methyl gallate with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibitory activities from a mushroom (Pholiota adiposa). Environ Toxicol Pharmacol. 2014 Mar;37(2):626-37. doi: 10.1016/j.etap.2014.01.023. Epub 2014 Feb 3. (Search PubMed)

  10. Yi L, Zhao J, Lu J, Chen Y, Chen L, Cheng J, Sun Y, Li Z, Men R, Yang L, Kung H, Yang Z1, He ML. Gene expression profiling of CD4⁺ T cells in treatment-naive HIV, HCV mono- or co-infected Chinese. . Virol J. 2014 Feb 13;11:27. doi: 10.1186/1743-422X-11-27. (Search PMC)

  11. Naftalin CM, Chan KC, Wong KH, Cheung SW, Chan RC, Lee SS. CYP2B6-G516T genotype influences plasma efavirenz concentration in a Hong Kong population, allowing potential individualization of therapy.HIV Med. 2014 Jan;15(1):63-4. doi: 10.1111/hiv.12076. (Search PubMed)

2013

  1. Lin P, Wong JH, Ng TB, Ho VS, Xia L. A sorghum xylanase inhibitor-like protein with highly potent antifungal, antitumor and HIV-1 reverse transcriptase inhibitory activities. Food Chem. 2013 Dec 1;141(3):2916-22. doi: 10.1016/j.foodchem.2013.04.013. Epub 2013 Jun 5. (Search PubMed)

  2. Au KY, Wang RR, Wong YT, Wong KB, Zheng YT, Shaw PC. Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells. Biochim Biophys Acta. 2013 Nov 15. pii: S0304-4165(13)00488-1. doi: 10.1016/j.bbagen.2013.11.005. (Search PubMed)

  3. Zhang Y, Yuan T, Li J, Zhang Y, Xu J, Shao Y, Chen Z, Zhang MY. The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development. AIDS. 2013 Oct 23;27(16):2529-39. doi: 10.1097/QAD.0000000000000015. (Search PubMed)

  4. To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC. Performance comparison of an in-house integrase genotyping assay versus the ViroSeq™ Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong. J Clin Virol. 2013 Sep;58(1):299-302. doi: 10.1016/j.jcv.2013.06.040. Epub 2013 Jul 22. (Search PubMed)

  5. Yuan T, Li J, Zhang MY. HIV-1 envelope glycoprotein variable loops are indispensable for envelope structural integrity and virus entry. PLoS One. 2013 Aug 1;8(8):e69789. doi: 10.1371/journal.pone.0069789. Print 2013. (Search PubMed)

  6. To SW, Chen JH, Wong KH, Chan KC, Chen Z, Yam WC. Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods. AIDS Res Hum Retroviruses. 2013 Aug;29(8):1123-8. doi: 10.1089/AID.2013.0067. Epub 2013 May 31. (Search PubMed)

  7. Zhou J, Cheung AK, Liu H, Tan Z, Tang X, Kang Y, Du Y, Wang H, Liu L, Chen Z. Potentiating functional antigen-specific CD8⁺ T cell immunity by a novel PD1 isoform-based fusion DNA vaccine. Mol Ther. 2013 Jul;21(7):1445-55. doi: 10.1038/mt.2013.63. Epub 2013 Apr 16. (Search PubMed)

  8. Zhou J, Cheung AK, Tan Z, Wang H, Yu W, Du Y, Kang Y, Lu X, Liu L, Yuen KY, Chen Z. PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice. J Clin Invest. 2013 Jun 3;123(6):2629-42. doi: 10.1172/JCI64704. Epub 2013 May 1. (Search PubMed)

  9. Lam SK, Ng TB. Purification and characterization of an antifungal peptide with potent antifungal activity but devoid of antiproliferative and HIV reverse transcriptase activities from Legumi secchi beans. Appl Biochem Biotechnol. 2013 Apr;169(7):2165-74. doi: 10.1007/s12010-013-0129-y. Epub 2013 Feb 15. (Search PubMed)

  10. Kang Y, Guo J, Chen Z. Closing the door to human immunodeficiency virus.  Protein Cell. 2013 Feb;4(2):86-102. doi: 10.1007/s13238-012-2111-9. Epub 2013 Mar 12. (Search PubMed)

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